In nucleotides and nucleic acids, syn-conformations and anti-conformations relate to rotation around the sugar-base bond.
The anti-conformations have a small pyrimidine or purine atom on the sugar ring, while the syn-conformations have a large pyrimidine or purine atom at that position. Pyrimidines occupy a narrow range of anti-conformations, whereas purines are found with a broader range of anti-conformations in nucleotides and nucleic acids.
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