A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm? (A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one translocated chromosome. (B) All will carry the same translocation as the father. (C) None will carry the translocation. (D) Half will be normal, and the rest will have the father's translocation.

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atsuedem3525 atsuedem3525

23-08-2022
Biology

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A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm? (A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one translocated chromosome. (B) All will carry the same translocation as the father. (C) None will carry the translocation. (D) Half will be normal, and the rest will have the father's translocation.

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AnnuG AnnuG · Answer 1 · 2022-08-31T04:46:45+02:00

Correct option a) (A) One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one trans-located chromosome.

Genetic carrier screening , prenatal screening for aneuploidy and prenatal diagnostic testing have expanded dramatically over the past two decades. The presence of chromosome abnormalities in couples with repeated spontaneous abortion is known even if the phenomenon is far from a complete assessment.

If gene on chromosome or on different chromosomes the recombination frequency 50% . Inheritance of alleles at the two loci are independent.One partner is carries of such balanced translocation have increased risks of infertility , and the chromosomal abnormal offspring.

Genetic counselor should answer to their consultants is to estimate the probability of recurrence of unfavorable pregnancy outcomes among their future pregnancies. The occurrence probability for individual carriers of two different autonomy- Autosome translocation with breakpoints at different positions by stengel- Rutkowaski et.

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