Bioinformatics can be used to scan for short sequences that specify known mRNAs. These are called expressed sequence tags. So the correct option is A.
Expressed sequence tags or ESTs are the portions in the sequences of mRNA that are derived from single sequencing reactions performed. These sequencing reactions are performed on clones which are randomly selected from cDNA libraries.
Till now, about 45 million ESTs have been produced using 1400 different species of eukaryotes. Mostly, the EST projects are as a complement to existing genome projects or to be used as a cheap alternative for gene discovery.
But, due to advances in the process of accuracy and coverage, their applications are beginning to increase in various fields. Some of these fields are Proteomics, phylogenetics and transcript profiling.
Therefore the correct option is A.
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