Respuesta :
Ethylene glycol is highly soluble because ethylene glycol can form hydrogen bonds with water.
What is solubility?
Despite the blunt SAR trait, medicinal chemistry may increase aqueous solubility, and our internal track record has been extremely effective in this regard. To increase solubility, chemists must commit to a mix of computational and experimental interventions, as well as make a concerted effort to incorporate solubility information into synthesis design. Given the existing inability to forecast computationally low solubility originating from crystal packing interactions, timely experimental feedback is especially critical. It is crucial not to overlook a coincidental improvement in solubility caused by a molecular change. Because of the blunt SAR characteristic, the simplest strategy to optimise solubility in library design is to strive to construct the optimal solubility profile from the start.
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