Consider a lab-made protein that contains an er signal sequence at its n-terminus and a nuclear localization signal in its middle. what is the initial fate of the protein?

Respuesta :

An mrnA molecule is attached to the er membrane by the ribosomes translating it. This ribosome population, however, is not static; the mrnA is continuously moved through the ribosome

Where is the signal sequence for proteins destined for the ER?

The endoplasmic reticulum (ER) is a network of tubules and sacs (cisternae) surrounded by membranes that extends from the nuclear membrane throughout the cytoplasm (Figure 9.1). The endoplasmic reticulum is the biggest organelle in most eukaryotic cells and is surrounded by a continuous membrane. Its membrane may constitute approximately half of all cell membranes, and the area encompassed by the ER (the lumen, or cisternal space) may be around 10% of total cell volume. As explained further below, there are two forms of ER that serve different tasks within the cell. The rough ER, which has ribosomes on its outside surface, is involved in protein digestion. The smooth ER is not linked to ribosomes and is engaged in lipid metabolism rather than protein metabolism.

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