Large proteins such as albumin remain in capillaries rather than diffusing out, resulting in the development of an osmotic pressure difference across capillary walls.
Albumin makes 54% of the plasma protein.
The albumin forms a pressure on the capillary walls called oncotic pressure.
The oncotic pressure is defined as a form of osmotic pressure induced by the proteins, notably albumin, in a blood vessel's plasma (blood/liquid) that causes a pull on fluid back into the capillary.
If there is a lesser amount of albumin in the capillaries the oncotic pressure will get disturbed and will cause a leak into the tissues, which is known as Oedema.
But this fluid is drained into the lymphatic system and it is returned to the blood circulation.
Thus, the proteins like albumin that remain in the capillary can lead to the development of osmotic pressure.
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