A nonfunctional CD4 protein on a helper T cell would result in the helper T cell being unable to option(d)i.e, interact with a class II MHC-antigen complex.
CD4 (cluster of differentiation 4) is a glycoprotein that functions as a co-receptor for the T-cell receptor in molecular biology (TCR). Immune cells such as T helper cells, monocytes, macrophages, and dendritic cells all have CD4 on their surface.
Additionally, the CD4 molecule serves a crucial functional purpose in the progression of HIV-1 infection. According to recent studies, the CD4 protein not only serves as the cell's receptor for HIV-1 but also actively takes part in post-binding processes that are crucial for infection and cell fusion.
It is ideal to have a high CD4 count and a low or undetectable viral load. The immune system is in better shape the greater the CD4 level. The likelihood that HIV medication is working increases with decreasing viral load.
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