Pyrethroid insecticides prevent the voltage-gated sodium channels of insects from inactivating. Neurons that were exposed to pyrethroids would not repolarize during action potential.
When the membrane reaches threshold the sodium channels open leading to influx of sodium into the membrane thus, depolarizing the membrane. In case if pyrethroids are applied that prevent inactivation of sodium channels then the positive charge inside the membrane increases as the channels remain open.
Which further prevents the repolarization process of the membrane and the action potential is disturbed. Therefore, the membrane is unable to close the channels and maintain its potential. For such an infected cell the repolarization step is never achieved.
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