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Symptoms of intense inflammation and shock occur in some gram-positive bacterial infections due to Superantigens.

Superantigens (SAgs) are a group of antigens that cause the immune system to become overactive. It specifically results in polyclonal T cell activation and significant cytokine production by non-specifically activating T cells. Some pathogenic viruses and bacteria create SAgs, perhaps as an immune system defence mechanism. Some common signs of bacterial infections include discomfort, fever, and enlarged lymph nodes. Depending on where in the body they occur, they may also produce certain other symptoms. Multidrug-resistant Gram-positive bacterial infections pose a significant public health risk in terms of morbidity and mortality, as well as increased costs for patient care and the deployment of infection control procedures.

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