The discoloration of the skin and sclera associated with jaundice is caused by excessive high level of bilirubin in the blood.
The bilirubin is a substance that has an orange yellow color and it is formed owing to the fact that the bile in humans is broken down. If there is an excess breakdown of the bile the bilirubin becomes excess.
Hence, the discoloration of the skin and sclera associated with jaundice is caused by excessive high level of bilirubin in the blood.
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