Changes in the structure and operation of several important brain systems, including the prefrontal and medial temporal lobe regions involved in working memory and declarative memory, respectively, have been linked to schizophrenia.
Schizophrenia is linked to alterations in the cortex's structure, function, and connections between various cortical regions. The nature, causes, and developmental course of these changes can now be better understood thanks to recent advancements in neuroimaging technologies. Observed structural abnormalities include decreased gray matter volume and altered white matter integrity; these alterations may occur both before the illness manifests and in the first few months after it does.
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