Periurethral bulking is the placement of small amounts of collagen in the urethral walls to aid the closing pressure.
Urethral bulking aims to improve urethral mucosal coaptation, and thus outlet resistance, in an effort to limit stress-induced leakage. While efforts have been made to employ bulking agents to treat stress urinary incontinence (SUI) for more than 100 years, we remain wanting for the perfect injectable. Efficacy is modest at best, repeat injections are the norm, and long-term follow up is conspicuously lacking.
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