The TBP gene codes for the production of a protein known as the TATA box binding protein. This protein is found in cells and tissues all over the body and plays an important role in regulating the activity of most genes.
TATA-binding protein is an RNA polymerase II subunit that aids in transcription initiation. When the TATA-binding protein binds to the TATA sequence in DNA, the DNA helix bends. TATA box-binding protein (TBP) is responsible for nucleating transcription initiation machinery assembly in eukaryotes. We show that a TFIID complex containing TBP is required for transcription even at promoters lacking a TATA box. The enzyme RNA polymerase is in charge of unwinding the two strands of DNA.
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