In the expression 3/3=_/21, it can be observed that 7 is multipled by denominator 3 in order to obtain 21 in in denominator. So same number, 7 is also multiplied with the numerator also.
[tex]\frac{3}{3}\times\frac{7}{7}=\frac{21}{21}[/tex]So, 21 is to be filled at blank space.