one of the potential limitations of case-control studies of the biological basis of disease is that the disease process may alter the exposure of interest. is that a concern for germline dna?

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21-11-2022
Biology

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one of the potential limitations of case-control studies of the biological basis of disease is that the disease process may alter the exposure of interest. is that a concern for germline dna?

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SancharyBhattacharya SancharyBhattacharya · Answer 1 · 2022-11-24T09:10:11+01:00

No. Our germline DNA remains constant. While humans may get mutations in particular cells, when DNA is extracted from a blood sample, it is DNA that we have had at birth and have inherited.

What is meant by the phrase germline?

... (JERM-line) The germ cell DNA (egg and sperm cells that join to form an embryo). All other cells in the body receive their DNA from the germline.

What distinguishes somatic from germline traits?

Changes to your DNA that you inherit from the sperm and egg cells during conception are known as germline mutations. Somatic mutations are modifications to your DNA that take place in cells other than the egg and sperm after conception.

Learn more about DNA here:

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