Respuesta :
Except by producing lysozyme, normal microbiota provide protection against infection in different ways.
How does lysozyme break down bacteria?
- Lysozyme damages or kills bacteria through its dual action as a lytic enzyme and small cationic protein by lysing cell wall peptidoglycan, disrupting bacterial membranes and activating autolytic enzymes in bacterial cell walls.
- Lysozyme, as an enzymatic globular protein, has attracted a great deal of attention in the pharmaceutical and food industries due to its antibacterial function. As reported, all lysozymes can hydrolyze the β-(1,4)-glycosidic bond between N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) in peptidoglycan chains.
- Lysozyme is active primarily against Gram-positive bacteria, but denaturation, chemical modification, or combination with other preservatives can extend its reach to Gram-negative bacteria.
What does lysozyme do in the immune system?
In addition to its direct antibacterial role, recent evidence indicates that lysozyme modulates the host's immune response to infection. Degradation and lysis of bacteria by lysozyme promotes the release of bacterial products, including PGs, that activate host cell pattern recognition receptors.
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