Respuesta :
Quinolone antibiotics is medication can damage the cartilage of children.
What is Quinolone antibiotics ?
The first quinolone antibiotics appeared in the early 1960s, and they had adverse pharmacokinetic qualities and a narrow spectrum of activity. Improved quinolone analogues with a broader scope and higher efficacy have been produced over time as a result of the discovery of new quinolone antibiotics. Quinolones are now often used to treat a range of illnesses. Quinolones are broad-spectrum antibiotics with activity against mycobacteria, anaerobes, and both Gram-positive and Gram-negative bacteria. They do this by interfering with the enzymes DNA gyrase and topoisomerase IV, preventing the production of nucleic acids by bacteria, and breaking bacterial chromosomes. However, due to abuse of these medications, bacteria have developed resistance to quinolones, just like they have to other antibacterial substances.
The chromosomal modifications and/or plasmid gene uptake that change the topoisomerase targets, modify the quinolone, and/or limit drug accumulation by either decreased uptake or higher efflux are the mechanisms causing quinolone resistance. The progress of this class of antibiotics in terms of potency, pharmacokinetics, and toxicity is discussed in this overview, along with the mechanisms of resistance that lessen the efficacy of quinolones against bacteria. Future generations of quinolone antibiotics with improved activity against resistant pathogens may employ the recommended approaches.
Quinolone antibiotics are usually not approved for use in children due to cartilage defects found in the weightbearing joints of juvenile animals given fluoroquinolones.
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