While glucagon increases NHGO primarily through increased glycogenolysis, epinephrine increases net hepatic glucose output (NHGO).
Epinephrine activates glycogen synthase (GS) when glycogen content is low, but it also stimulates glycogen breakdown and decreases GS activity.
Glucagon Increases Hepatic Glucose Production More specifically, glucagon encourages the liver to convert glycogen to glucose (glycogenolysis), stimulates de novo glucose synthesis (gluconeogenesis), and prevents the breakdown of glucose (glycolysis) and the formation of glycogen (glycogenesis).
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