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Which of the choices below correctly describes how an action potential generated at the neuromuscular junction (NMJ) is converted to excitation in the muscle fiber?
An action potential in the motor neuron causes ACh to be released into the synaptic cleft. Binding of ACh to sarcolemma receptors initiates graded potentials.

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When an action potential is conveyed to the axon terminus, depolarization causes voltage-gated calcium channels to open and conduct an influx of calcium, allowing the vesicles carrying acetylcholine to be released into the synaptic cleft with a chemical transmitter(ACh)

Acetylcholine (ACh), a chemical transmitter, is released into the synaptic cleft as a result of the action potential. ACh diffuses through the post synaptic or postjunctional membrane and binds to specific receptors there. A membrane channel particularly undergoes a conformational change upon ACh binding to its receptors.

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ACh is activated cleft in response to with an action potential inside the motor neuron.

Voltage-gated calcium channels open and transmit an influx of calcium when an action potential is sent to the axon terminus neuron, allowing synaptic vesicle carrying acetylcholine to be discharged into the synaptic gap with such a chemical transmitter (ACh).The action potential cleft causes the chemical transmitter acetylcholine (ACh) to be released into to the synaptic cleft.  ACh is activated cleft in response to with an action potential inside the motor neuron transmitter.ACh binds to certain receptors in the idea of this approach or postjunctional membrane after diffusing through it. When ACh binds to a membrane channel's receptors, the channel changes conformation.

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