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The correct option is Endocrine glands must be close to the target cells on which they exert effects.
What are endocrine glands?
Endocrine glands are also known as the ductless glands because of the fact that their secretions are released directly into the blood, not to any tubes or ducts. The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neural control center for all endocrine systems. Local chemical messengers, not generally considered part of the endocrine system, include autocrines, which act on the cells that secrete them, and paracrines, which act on a different cell type nearby. The endocrine glands belong to the body's control system. The hormones which they produce help to regulate the functions of cells and tissues throughout the body.
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