Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types.
Determination occurs before differentiation, determination gives an operational definition, and commits cell to a subset of cell types at this stage.
Determination occurs when the fate of a cell is already fixed, differentiation is when the cell actually becomes the cell it is meant to be.
Differentiation occurs numerous times during the development of a multicellular organism.
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