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During the time when the South seceded from the Union, the relationship between the North and the South was highly contentious and marked by significant tensions. The secession of Southern states, which culminated in the formation of the Confederate States of America, was primarily driven by the issue of slavery and the desire to maintain and expand the institution.

The North, represented by the Union, opposed the secession and sought to preserve the integrity of the United States. The Northern states, particularly those in the industrialized and more urbanized regions, generally held a more progressive and abolitionist stance on slavery. They viewed secession as an act of rebellion against the Union and a threat to the principles of the United States.

The South, on the other hand, saw the secession as a defense of their perceived rights and interests, including the preservation of slavery as an integral part of their economy and society. They felt that their states' rights were being infringed upon by the Northern states, and they believed in the concept of states' sovereignty.

The secession led to the outbreak of the American Civil War in 1861, a devastating conflict between the Union and the Confederacy. The war further strained the relationship between the North and the South, with both sides engaging in fierce military confrontations and ideological battles.

Overall, the secession of the South deepened the divisions between the North and the South, leading to a protracted and bloody conflict that had profound social, economic, and political ramifications for the United States. It took years of fighting and reconciliation efforts to rebuild the relationship between the North and the South following the end of the Civil War.