In the question of -conoces a maria? the response is -Si, la conozco desde hace tiempo.
The statement was -conoces a maria? -Si, la conozco desde hace tiempo which means in English as -do you know maria? -Yes, I've known her for a long time.
The response to put there is have because it is the right tense to use and as such, In the question of -conoces a maria? the response is -Si, la conozco desde hace tiempo is correct.
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