Respuesta :

Los zapatos son de cueros

Leather in Spanish is
cuero, but remember this sentence is in plural form so...cueros is the answer.
Los zapatos son de cueros
Cueros fills in the blank.

Which translates to: "The leather shoes". 
Since it's 'zapatos', and not, "zapato"--meaning its more than one shoe-- you need to make sure cuero agrees with zapatos. Adding an s at the end makes it plura, so the whole sentence is in correct tense. 

Hope this helps!