How does comparative genomics aid in the search for factors that contribute to complex human conditions?

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23-11-2017
Biology

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How does comparative genomics aid in the search for factors that contribute to complex human conditions?

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W0lf93 W0lf93 · Answer 1 · 2017-12-02T18:58:49+01:00

After the examination of the human genome became possible, scientists could compare the genes of "normal" individuals with the genes of individuals with disorders. Once scientists know where the gene is affected, they can determine the factors that could have impacted that specific portion of the gene. They can examine the genes of family members of each individual to see if conditions are determinedly hereditary or if environmental factors may play a role.

nimamprayogo nimamprayogo · Answer 2 · 2020-02-23T16:43:03+01:00

When the human genome allows for examination, scientists make comparisons between individual genes and genes that have abnormalities. That way, the comparison made in the examination of the genome will show the results regarding the areas of the gene that are affected due to certain factors. The results of these tests are carried out to determine whether genes are influenced by offspring or environmental factors.

Further Explanation

The Human Body is a Mosaic of Various Genomes

Tissue mosaics arise when cells accumulate mutations - from DNA errors that propagate during cell division, or because of exposure to environmental factors such as ultraviolet light or cigarette smoke. When a skin cell with a given mutation divides, it can make skin patches that are genetically different from its neighbors.

Previous studies have found high levels of mosaicism in the skin, esophagus, and blood. These results are usually obtained by sequencing special genes in microscopic tissue samples.

Tissues with high cell division rates, such as those that make up the skin and esophagus, tend to have more mosaicism than tissues with lower cell division rates.

Mosaicism also increases with age and is particularly prevalent in the lungs and skin tissue which are affected by environmental factors that can damage DNA.

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Mosaicism https://brainly.com/question/7249894#

Human Genome https://brainly.com/question/7249894#

Details

Grade: High School

Subject: Biology

Keyword: genome, human, mosaicism