In 1966, charles whitman killed his wife, his mother, and 14 more people at the university of texas before he was killed by police. an autopsy revealed that a tumor affecting whitman's ________ was likely the cause for the ________behind his killing spree.

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The correct answers are amygdala and motivation. 
Amygdala is part of human brain responsible for many things, the most important of which (for your question) are decision-making and emotional response. Given that Whitman had a tumor which was affecting his amygdala, he couldn't really think straight and the motivation behind his crimes was likely due to this tumor.