Answer
The problems associated with sickle-cell anemia are oxygen respiration and blood circulation
Explanation
Sickle-cell anemia is an inherited type of anemia where there is inadequate healthy red blood cells to carry enough oxygen through the body. Oxygen respiration and blood circulation are affected because sickle cell break apart easily and die leaving the individual with inadequate red blood cell. This shortage of red blood cells will prevent the body from getting the oxygen it requires causing fatigue.
