Sickle cell anemia is caused by an abnormal hemoglobin in red blood cells. hemoglobin is the red pigment found in red blood cells for carrying oxygen.The abnormality arises from a genetic mutation in the DNA gene that codes for the beta chain of the protein called globin of which hemoglobin is made of.In the beta chain, the sixth amino acid called glutamine is replaced by another one called valine.This one change in the amino acids cause the hemoglobin protein to behave abnormally, causing red blood cells to lose their normal spherical shape and become bent like a sickle, hence the name "sickle cell" anemia
