In aggressive forms of breast cancer, the gene encoding a protein called stathmin is overexpressed. Inhibiting expression of the stathmin gene arrests cells in M phase and is being investigated as an alternative therapy for treating cancer. What additional genes could be therapeutic targets that, when inactivated, would arrest cancerous cells in G1 phase?

Inactivating genes that code for cyclin proteins (in this case cyclins -type D) would arrest a cell in G1 phase. The type D cyclins are responsible for activating cyclin-dependent-kinases 4 and 6 responsible for the progression of a cell through the G1 phase to S phase.

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kasliwalalvi24 kasliwalalvi24 · Answer 2 · 2021-10-18T12:50:30+02:00

Stathmin protein plays a crucial role in the regulation of the microtubule cytoskeleton. The aggressive form of breast cancer is caused due to the overexpression of stathmin. The genes that code for cyclin complexes are arrested in the G1 phase.

The G1-phase arrest is a type of mechanism in which cells undergo repair mechanisms or follow the apoptotic route. The type D cyclins are responsible for the activation of cyclin-dependent kinases. These complexes are responsible for the progression of cells through G1 to S phases.

The stathmin overexpression leads to breast cancer. The inhibition of the gene is done by:

The gene encoding for stathmin arrests the cells in the M phase. The technique is being used to treat breast cancer.
The surgeries and chemotherapy are used to treat breast cancer otherwise.

Therefore, to know more about the cell arrest and cell cycle, refer to the following link:

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