Respuesta :

DNA molecules can coil and bend in space, leading to changes in topology, including formation of negative or positive supercoils. For example, as discussed in Chapter 4, local unwinding of a DNAduplex whose ends are fixed causes stress that is relieved by supercoiling. The enzymes that control the topology of DNA
Different types of topoisomerases have different functions and these include accessing DNA, recombination process strand breakage, removing DNA supercoils, chromosome condensation and detangling intertwined DNA. All forms of topoisomerases are a type of enzyme responsible for DNA supercoiling regulation.