Answer:
The following two enzymes, cyclooxygenase and lipoxygenase, then convert it to various eicosanoids. Some peptide hormones and other stimuli liberate arachidonic acid from one of the phospholipids of the plasma membrane.
Explanation:
Lipoxygenase then converts arachidonic acid into leukotrienes. These leukotrienes mediate immune response to allergies and inflammation by activating leukocytes and increasing vascular permeability-
Cyclooxygenase (COX) converts arachidonic acid into prostacyclin and thromboxane, which have a key role in platelet aggregation and vascular smooth muscle contraction. COX also converts arachidonic acid into prostaglandins, which mediate immune response to allergy.
The following two enzymes, cyclooxygenase, and lipoxygenase, then convert it to various eicosanoids. Some peptide hormones and other stimuli liberate arachidonic acid from one of the phospholipids of the plasma membrane.
Enzymes are protein substances that act as catalysts that are needed to speed up the rate of biological reactions without being changed in the process.
Eicosanoids are biologically active secondary metabolites(e.g C20) of arachidonic acid, a membrane polyunsaturated fatty acid, and are produced by three primary enzymatic pathways:
These eicosanoids regulate vascular function by activating G-protein coupled receptors in endothelial cells and vascular smooth muscle cells such as the plasma membrane of the renal system.
Cyclooxygenase (COX) is an enzyme that transforms arachidonic acid into prostacyclin and thromboxane, both of which play important roles in platelet formation and vascular smooth muscle contraction.
Lipoxygenase then transforms arachidonic acid to leukotrienes. These leukotrienes modulate the immunological response to allergens and inflammation by stimulating leukocytes, thereby increasing vascular permeability.
Arachidonic acid is mostly released by phospholipase A2, which is regulated by hormonal and paracrine factors.
Therefore, we can conclude that we have understood the mechanism of the cyclooxygenase, and lipoxygenase, are being converted to various eicosanoids.
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