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Based on the information given in the three different sections, which of the following statement(s) correctly describe(s) the hit that is most similar to the query sequence? Select all that apply.

Respuesta :

safiurrehman

NOTE: QUESTION IS INCOMPLETE I HAVE ADDED FULL QUESTION IN THE ASK FOR DETAIL SECTION.

Answer:

Followings are the true options:

  1. It is identical to the query sequence in length and amino acid sequence.
  2. It is a chimeric protein.
  3. Its accession number is CAM33009.1.

Explanation:

This question is about sequence analysis. I have retrieved full sequence from National Center for Biotechnology Information (NCBI) library. I used accession number CAM33009.1 which is true and exist on NCBI data base.

Here is the full detail about it.:

Name: bcr-abl1 e13a3 chimeric protein, partial [Homo sapiens]

human

No of Proteins: 235 aa protein

Accession Number: CAM33009.1

LOCUS      CAM33009                 235 aa            linear   PRI 14-JUL-2016

DEFINITION bcr-abl1 e13a3 chimeric protein, partial [Homo sapiens].

ACCESSION   CAM33009

VERSION     CAM33009.1

DBSOURCE   embl accession AM491359.1

KEYWORDS    .

SOURCE      Homo sapiens (human)

 ORGANISM Homo sapiens

           Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;

           Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;

           Catarrhini; Hominidae; Homo.

REFERENCE   1

 AUTHORS   Burmeister,T. and Reinhardt,R.

 TITLE     A multiplex PCR for improved detection of typical and atypical

           BCR-ABL fusion transcripts

 JOURNAL   Leuk. Res. 32 (4), 579-585 (2008)

  PUBMED   17928051

REFERENCE   2  (residues 1 to 235)

 AUTHORS   Burmeister,T.

 TITLE     Direct Submission

 JOURNAL   Submitted (02-FEB-2007) Burmeister T., Medizinische Klinik III,

           Charite Universitaetsmedizin Berlin, CBF, Hindenburgdamm 30, 12200

           Berlin, GERMANY

FEATURES             Location/Qualifiers

   source          1..235

                    /organism="Homo sapiens"

                    /db_xref="taxon:9606"

                    /cell_type="leukocyte"

                    /note="fusion of BCR exon 13 and ABL1 exon 3"

    Protein        <1..>235

                    /product="bcr-abl1 e13a3 chimeric protein"

                    /function="tyrosine kinase, oncogene"

    Region          <1..48

                    /region_name="PH-like"

                    /note="Pleckstrin homology-like domain; cl17171"

                    /db_xref="CDD:302622"

    Region         <72..107

                    /region_name="SH3"

                    /note="Src Homology 3 domain superfamily; cl17036"

                    /db_xref="CDD:302595"

    Region         112..205

                    /region_name="SH2_ABL"

                    /note="Src homology 2 (SH2) domain found in Abelson murine

                    lymphosarcoma virus (ABL) proteins; cd09935"

                    /db_xref="CDD:198189"

    Site           order(123,151,164)

                    /site_type="other"

                    /note="phosphotyrosine binding pocket [polypeptide

                    binding]"

                    /db_xref="CDD:198189"

    CDS            1..235

                    /gene="BCR-ABL1"

                    /coded_by="AM491359.1:<1..>707"

                    /db_xref="GOA:A2RQD3"

                    /db_xref="InterPro:IPR000980"

                    /db_xref="InterPro:IPR001452"

                    /db_xref="InterPro:IPR001849"

                    /db_xref="InterPro:IPR020685"

                    /db_xref="InterPro:IPR020700"

                    /db_xref="UniProtKB/TrEMBL:A2RQD3"

ORIGIN      

       1 psmafrvhsr ngksytflis sdyeraewre nireqqkkcf rsfsltsvel qmltnscvkl

      61 qtvhsiplti nkegeklrvl gynhngewce aqtkngqgwv psnyitpans lekhswyhgp

     121 vsrnaaeyll ssgingsflv resesspgqr sislryegrv yhyrintasd gklyvssesr

     181 fntlaelvhh hstvadglit tlhypapkrn kptvygvspn ydkwemertd itmkh

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