Colon cancer is caused by the accumulation of multiple gene mutations that result in uncontrolled cell division and growth. Arrange the steps of colon cancer progression

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23-05-2022
Biology

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Colon cancer is caused by the accumulation of multiple gene mutations that result in uncontrolled cell division and growth. Arrange the steps of colon cancer progression

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saimaparvezVT saimaparvezVT · Answer 1 · 2022-05-27T08:39:08+02:00

Colon cancer is caused by the accumulation of multiple gene mutations that result in uncontrolled cell division and growth as they are all arranged are colon tissues.

What is APC gene?

The APC gene is a tumor suppressor gene; it usually allows preserve cell increase in check. In humans with inherited modifications withinside the APC gene, this “brake” on cell increase is became off, inflicting loads of polyps to shape withinside the colon. Over time, most cancers will almost continually expand in a single or greater of those polyps.

Colon tissue is to begin with healthy.
Polyps or early adenomas are fashioned with the aid of using mutations in APC.
Late adenomas are fashioned with the aid of using the inactivation of DCC and Smad4.
Colon most cancers invades neighboring tissues.
Adenocarcinomas end up metastatic with the aid of using unknown mutations.
Adenocarcinomas are generated with the aid of using mutations in p53.
Intermediate adenomas are with the aid of using mutations.