In the reaction catalyzed by the pyruvate dehydrogenase complex, the two carbons constituting the acetyl group are.

Respuesta :

In the reaction catalyzed by the pyruvate dehydrogenase complex, the two carbons constituting the acetyl group are oxidized by NAD+ while attached to the lipoamide.

Pyruvate dehydrogenase influencing the reaction:

A multienzyme complex called pyruvate dehydrogenase (PDH) catalyzes the oxidative conversion of pyruvate into acetyl coenzyme A (CoA), carbon dioxide (CO2), and reducing equivalents in the form of NADH.

Reaction:

  • The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to the acetyl group of acetyl-CoA.
  • This complex requires the sequential action of three different enzymes and five different enzymes and five different coenzymes or prosthetic groups - Thiamine pyrophosphate(TPP), flavin adenine dinucleotide(FAD), coenzyme A(CoA-SH), Nicotinamide adenine dinucleotide(NAD).

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