A frameshift mutation alters the open reading frame of a DNA sequence by adding or removing nucleotides. A deletion is a mutation that occurs when one nucleotide from the DNA sequence is removed.
Frameshift mutations, which alter the ribosome reading frame and cause premature translation termination at a new nonsense or chain termination codon, are deletions or additions of 1, 2, or 4 nucleotides (TAA, TAG, and TGA).
The reading frame, a grouping of nucleotides, might shift out of alignment as a result of mutations (changes in the DNA sequence), rendering the gene sequence unintelligible. Insertions (the addition of extra nucleotides) and deletions (the loss of one or more nucleotides) are the two different kinds of frameshift mutations.
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